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ITKTubeTK is an open-source toolkit for the segmentation, registration, and analysis of tubes and surfaces in images. Tubes and surfaces, as generalized 1D and 2D manifolds in N-dimensional images, are essential components in a variety of image analysis tasks. Instances of tubular structures in ... [More] images include blood vessels in magnetic resonance angiograms and b-mode ultrasound images, wires in microscopy images of integrated circuits, roads in areal photographs, and nerves in confocal microscopy. [Less]